A dehydrated extracellular amniotic allograft membrane for use as a scaffold for ocular repair
Vendaje OPTIC™ is a dehydrated, extracellular membrane allograft for use as a scaffold for ocular repair. The allograft is derived from human placental tissue, preserved to maintain the structural properties of the biologically active elements present in tissue regeneration.
Vendaje OPTIC™ is made up of three layers: epithelium, basement membrane, and stroma. Several types of collagen make up the basement membrane, including type VII collagen, which is also present in the conjunctival and corneal basement membranes. The stroma of Vendaje Optic™ can be subdivided further into a compact layer, a fibroblast layer, and an outer spongy layer.
Single amniotic membrane layer
Contains full spectrum of growth factors
150 microns in thickness
Bioscaffold containing extracellular matrix
High tensile strength
Anti-fibrotic and anti-adhesion barrier
Moderate levels of fibronectin and laminin5
No immune rejection2-4
2 The immunology of successful pregnancy. Veenstra van Nieuwenhoven AL, Heineman MJ, Faas MM. Hum Reprod Update. 2003;9:347–357.
3 Immunogenicity of human amniotic membrane in experimental xenotransplantation. Kubo M, Sonoda Y, Muramatsu R, Usui M. Invest Ophthalmol Vis Sci. 2001;42:1539–1546.
4 Immunological characteristics of amniotic epithelium. Hori J, Wang M, Kamiya K, Takahashi H, Sakuragawa N. Cornea. 2006;25:0–58.
5 Olczyk P, Mencner Ł, Komosinska-Vassev K. The role of the extracellular matrix components in cutaneous wound healing. Biomed Res Int. 2014;2014:747584. doi:10.1155/2014/747584